About the Diagnosis
The pancreas is an organ in the abdomen that produces substances that are critical for
digestion and for the body’s normal metabolism. Microscopically, the pancreatic tissue
is composed of two intermingled parts: exocrine and endocrine.
Exocrine pancreatic tissue is responsible for producing and releasing enzymes
(digestive juices) that help to break down and digest food in the intestine. Appropriate
digestion permits nutrients to be absorbed and used by the body, and in this way, the
pancreas is essential for transforming food into energy and building blocks that the body
can use. The endocrine pancreatic tissue produces hormones that circulate in the
bloodstream and are necessary for vital processes such as blood sugar (glucose)
Cause: In dogs, pancreatic exocrine insufficiency is caused by degeneration (atrophy)
of the cells that produce digestive enzymes (pancreatic acinar cells, which are part of
the exocrine pancreatic tissue). The exact reason why these cells waste away is not
known. Exocrine pancreatic insufficiency (also called EPI, pancreatic exocrine
insufficiency, or PEI) may be genetically transmitted in German shepherds and rough-
coated collies, and symptoms of the disease may be evident by 2 years of age in these
However, this disease can develop in any dog breed. In cats, pancreatic exocrine
insufficiency is thought to be caused most commonly by chronic inflammation of the
acinar cells of the pancreas and is very rare.
Although dogs and cats with this disorder tend to have healthy to ravenous appetites,
weight loss is common. The body cannot utilize the food that an animal eats because
the absence of pancreatic enzymes (digestive juices) means the food is not properly
digested or absorbed. That is, the actual intake of food is adequate or even higher than
normal, but the food is not taken up properly and is excreted in the feces largely
undigested. As a result, animals with pancreatic exocrine insufficiency may ingest their
own feces (coprophagia) or unusual material such as dirt (pica) in an attempt to
compensate for nutritional deficiencies. A thin body condition and a poor hair coat are
common results. The volume of feces (stool, excrement, bowel movements) may be
normal or increased, and feces may be gray or yellow. Frequent bowel movements,
diarrhea, and flatulence also commonly occur as part of exocrine pancreatic
Diagnosis: Your veterinarian will perform a thorough physical examination of your dog,
and take a complete medical history of your dog from you, asking you questions such
as the duration and appearance of symptoms you have observed, whether you have
given any medications and if so, whether any effect was apparent, and so on. To
determine your pet’s general health status and to rule out other problems in the
abdomen that could cause similar symptoms, routine blood tests such as a complete
blood test (CBC) and blood chemistry profile, a urinalysis, and x-rays or ultrasound
exam of the abdomen (belly) and chest may be performed. These are often necessary
because the symptoms of exocrine pancreatic insufficiency are nonspecific; many other
diseases may imitate exocrine pancreatic insufficiency, and since they are more
common, they often are checked for using the tests just listed.
Microscopic analysis of a sample of your pet’s feces may be done to check for parasites
(a common “impostor” that causes symptoms identical to pancreatic exocrine
insufficiency) and to look for undigested fats and starch. The most reliable test for
pancreatic exocrine insufficiency is a blood test that measures the circulating levels of
pancreatic enzymes (substances that are produced by the pancreas for digestion).
This test is called the serum trypsin-like immunoreactivity (TLI) assay. Normal healthy
individuals have a certain background level of these enzymes in the bloodstream at all
times, whereas patients with pancreatic exocrine insufficiency are mostly or entirely
deficient in the enzymes, as the blood test reveals. Rarely, some results are
indeterminate, and a second sample may need to be tested at a later date.
Living with the Diagnosis
When it is identified early and treated properly, pancreatic exocrine insufficiency is not a
life-threatening disorder. Most dogs and cats diagnosed with pancreatic exocrine
insufficiency respond well to treatment (see Treatment), and once treatment is
underway, most individuals enjoy an absolutely normal quality of life and normal life
expectancy. The pancreas often does not regenerate when it is affected by exocrine
pancreatic insufficiency, and treatment is typically required for the life of the pet.
Relapses may occur and can be caused by forgetting to give the enzyme supplement
treatment or the development of complications such as bacterial overgrowth in the
intestine or other digestive upsets that occur from time to time.
Treatment given every day is essential and simple. It consists of adding replacement
pancreatic enzymes directly to the food because the pancreas does not make the
enzymes when affected with exocrine pancreatic insufficiency. Pancreatic enzymes are
simply supplemented in the diet. These enzymes are available as powder, capsules,
and tablets, and the treatment simply consists of putting the enzymes in/on the food,
every meal, just before feeding your dog. Diet modification may be necessary as well
since some foods are better tolerated than others when patients have exocrine
pancreatic insufficiency (consult your veterinarian).
Antibiotics may sometimes be given for the first several weeks of treatment. Cats may
require additional supplements. Your veterinarian can discuss these nutritional
requirements with you.
Your dog or cat’s treatment protocol may need to be changed several times before the
best regimen is found. Your veterinarian can tailor treatment for your pet as needed,
and periodic rechecks are needed for this reason.
Realize that pancreatic exocrine insufficiency is not a life-threatening condition when it
is diagnosed early and treated and monitored properly. Affected pets generally live
normal lives with enzyme supplementation on every meal.
Inform your veterinarian if your cat or dog has ever been diagnosed with a medical
condition and is taking medication, as these could be affected by exocrine pancreatic
Give medication and enzyme supplements exactly as directed by your veterinarian, and
if you are concerned about possible negative effects, discuss them with your
veterinarian immediately rather than simply discontinuing the treatment. It is a mistake
to feel that the treatment can be stopped when the symptoms resolve, because
exocrine pancreatic insufficiency is generally permanent.
If you have several dogs that run together in a yard and you are having trouble
determining which dog has abnormal feces (e.g., diarrhea), you may feed each dog half
a nontoxic wax crayon (different colors—keep track of who gets which one), and the
colors will appear in the feces to identify whose is abnormal.
If treatment is not working or symptoms are different from those expected for exocrine
pancreatic insufficiency, you may want to speak to your veterinarian about seeking a
Do not postpone visiting your veterinarian if you observe any symptoms of pancreatic
exocrine insufficiency in your dog or cat. Prolonged malnutrition can have severe
Do not give medication that you have at home that has been prescribed for human use;
some of these may interfere with treatment and cause even more severe problems.
When to Call Your Veterinarian
If you cannot keep a scheduled appointment.
If you are unable to give pancreatic enzymes or medication as directed.
If your dog or cat is not improving after treatment begins.
Signs to Watch For
As general signs of illness that could indicate uncontrolled exocrine pancreatic
insufficiency, or a totally different disorder that partially mimicked exocrine pancreatic
insufficiency: lethargy, weakness, vomiting, hiding more than usual, aggressiveness,
and other behavior changes.
Signs of uncontrolled exocrine pancreatic insufficiency, warranting a recheck and
adjustment to treatment (increase or change enzyme supplementation): weight loss
despite an increased appetite; increased volume and/or frequency of feces; eating
feces, dirt, or other foreign materials; flatulence; frequently “growling” stomach
(borborygmus); and poor hair coat quality.
Follow-up appointments are typically scheduled to monitor progress. Treatment may be
adjusted based on findings at follow-up visits. Once the condition is stable and
symptoms are gone, rechecks are usually annual or semiannual.